Histoplasmosis - Treatment

What was the treatment for your histoplasmosis?

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How is histoplasmosis treated?

For asymptomatic people or people with acute localized infection who are otherwise healthy, antifungal treatment is usually not recommended as these people have or will resolve the infection in about three weeks. If symptoms persist a month or more, itraconazole (Sporanox), ketoconazole (Nizoral) or amphotericin B (Fungizone, Amphocin) may be effective. If CNS involvement occurs, or if the person is compromised by other diseases or is immunocompromised and has severe histoplasmosis (progressive disseminated histoplasmosis), either itraconazole or amphotericin B is recommended. The lengths of time, dosing amounts, and dosing routes are usually individualized for the patient; consultations with both infectious disease and pulmonary specialists are recommended. Other new azole compound drugs may be effective in some difficult or unresponsive cases; the consultants could help select the appropriate new drug treatment.

Surgery has been used to treat some complications seen in some cases of histoplasmosis. Examples of surgical procedures include pericardiocentesis or a pericardial window procedure (both designed to remove fluid that compresses the heart) in the few patients that develop pericarditis; resection of cavitary lung lesions; excision of lymph nodes that compress pulmonary, vascular, or other structures; and replacement of damaged heart valves or other structures.

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Comment from: grannybradford, 55-64 Female (Patient) Published: October 18

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