Schistosomiasis - Treatment

What kinds of treatment did you receive for your schistosomiasis?

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What is the treatment for schistosomiasis?

Currently, the drug used in most people is praziquantel (Biltricide); however, it only is effective against adult worms and does not affect eggs or immature worms. Treatment with this drug is simple and its dose is based on the patient's weight with two doses given on one day. However, the drug causes rapid disintegration of the worm which, in turn, allows the human immune system to attack the parasite. This immune response can cause localized reactions, which may increase the patients' symptoms. Corticosteroids are often used to reduce the symptoms of this reaction. Unfortunately, this response limits the use of praziquantel. Praziquantel and oxaminquine or artemether are used by some clinicians early in infections, or to treat individuals infected with both malaria and schistosomes, respectively.

Ocular schistosomiasis should not be treated with this praziquantel; other organs with heavy parasite infections may not function well and require supportive care until the hyperimmune response abates after drug administration. Other drugs (oxamniquine, metrifonate, artemisinins, and trioxolanes) have been used in some patients but have limited effectiveness. New drugs are in development.

Surgical care may include removal of tumor masses, ligation of esophageal varices, shunt surgeries, and granuloma removal.

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