Erythema Nodosum - Experience

Not ready to share? Read other Patient Comments

Please describe your experience with erythema nodosum.

Share your story with others:

MedicineNet appreciates your comment. Your comment may be displayed on the site and will always be published anonymously.Patient Comments FAQs

Enter your Comment

Tell us a bit about your background to make your comments more useful to other MedicineNet users. (Optional)

Screen Name: *

Gender of Patient: Male Female

Age Range of Patient:

I am a: Patient Caregiver


* Screen Name will appear next to the published comment. Please do not include your full name or email address.

By submitting your comment, and other materials (collectively referred to as a "Submission") to MedicineNet, you grant MedicineNet permission to use, copy, transmit, publish, display, edit and modify your Submission in connection with its Web site. MedicineNet will not pay you for your Submission. You represent that you have all rights necessary for MedicineNet to use your Submission as set forth above.

Please keep these guidelines in mind when writing your comment:

  • Please make sure you address the question asked.
  • Due to the overwhelming number of comments received, not all comments will be published.
  • When selecting comments to publish, our staff will choose those that are educational and complement the topic. Please try to stay on topic.
  • Your comment may be edited. We would typically edit comments to make them clearer and more readable. We will remove personal information such as last names, email and web addresses, and other potentially harmful information.
  • We will not notify you if your comment has been published. We suggest that you check back on the topic article regularly.
  • We do not provide medical or healthcare advice, treatment, or diagnosis.

Thank you for participating!


I have read and agree to abide by the MedicineNet Terms and Conditions and the MedicineNet Privacy Policy (required).

To prevent our systems from spam, please complete the following prior to submitting your comment.

Please select the white triangle:

What is erythema nodosum?

Erythema nodosum is a type of skin inflammation that is located in a certain portion of the fatty layer of skin. Erythema nodosum (also called EN) results in reddish, painful, tender lumps most commonly located in the front of the legs below the knees. The tender lumps, or nodules, of erythema nodosum range in size from one to five centimeters. The nodular swelling is caused by a special pattern of inflammation in the fatty layer of skin.

Erythema nodosum can be self-limited and resolve on its own in three to six weeks. Upon resolution, it may leave only a temporary bruised appearance or leave a chronic indentation in the skin where the fatty layer has been injured.

Return to Erythema Nodosum

See what others are saying

Comment from: CDH, 55-64 Female (Patient) Published: January 23

I first got EN (erythema nodosum) in 2007 after walking through a natural wetlands. I was 51 and towards the end of menopause. I kept sniffing my nose while walking through the wetlands so there was lots of mucus in my nose. A few weeks later I got the first red spots on my legs that felt like bruises. It took over six months to get properly diagnosed and by then I was chronic. I went to several doctors before I found out what it was. By then I had it all over my body. I could not walk very well and had pain everywhere especially my hands, legs and feet. I was put on prednisone which was gradually increased up to 30 mgs per day for months. I was finally sent to a rheumatologist who put me on methotrexate, a medication used for arthritis. I got 25 mg injections once per week for just over two years. It just came back in the fall of 2013. I am going back on methotrexate 7.5 mgs now because it's not going away on its own. This medication is taken once per week. I am also taking a steroid pack to keep my immune system back some. This is extremely painful. There has been no underlying cause diagnosed; however, I believe I inhaled some type of fungus while walking through the wetlands and my hormones were wacky from menopause. I believe it came back because of stress. Last two years of my life have been extremely stressful and emotionally difficult.

Was this comment helpful?Yes
Comment from: momoffour, 55-64 Female (Patient) Published: May 22

I first got erythema nodosum (EN) in 1980 at the age of 30. I had 6 nodes in one calf and 7 in the other. I was fitted for surgical stockings for the swelling. Every spring after that it came back with a vengeance. Through trial and error, I learned that (1) at times I was taking a sulfa drug that caused it, and (2) that I was allergic to something that was in the air in the springtime. I took allergy tests (400 allergens) and was given a serum made of my allergy suspects in order to develop my immune system. For the nine months I was taking the shots, my EN did not go away. For me, taking Keflex as long as needed (as much as 6 weeks), has been the best treatment. Today, after thirty four years, it is back again, thanks to an allergy and springtime! In those 34 years I have had five doctors misdiagnose it as thrombophlebitis and try to get me to take blood thinners! Thank goodness I found that dermatologist!

Was this comment helpful?Yes

STAY INFORMED

Get the latest health and medical information delivered direct to your inbox!