Primary Biliary Cirrhosis - Symptoms

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Please describe the symptoms of your primary biliary cirrhosis.

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What are the symptoms and physical findings in PBC?

The symptoms and physical signs (findings) in patients with PBC can be divided into those manifestations due to:

  • PBC itself
  • Complications of cirrhosis in PBC
  • Diseases often associated with PBC
The multiple signs and symptoms (manifestations) of primary biliary cirrhosis, its associated diseases, and the complications of the cirrhosis
Primary Biliary Cirrhosis Associated Diseases Complications of Cirrhosis
Fatigue Thyroid dysfunction Edema and ascites
Itching Sicca syndrome Bleeding from varices
Metabolic bone disease Raynaud's phenomenon Hepatic encephalopathy
Xanthomas Scleroderma Hypersplenism
Fat and vitamin absorption Rheumatoid arthritis Hepatocellular carcinoma
Jaundice Celiac sprue
Hyperpigmentation Inflammatory bowel disease
Urinary tract infection

Patients with PBC, however, very often do not have any symptoms. In the large study of 770 patients with PBC in northern England, 56% had no symptoms at the time of diagnosis.

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See what others are saying

Comment from: chrsgonz1, Female (Patient) Published: August 12

I am a 38 year old female. I found out that I have PBC about 3 years ago. I have had 2 liver Biopsys and several blood tests. I was told 3 years ago that I was at stage 1 maybe 2. My father has passed away from Hepatitis non A non B. Not sure what that means or if it has anything to do with me now? I have noticed that lately that I am more tired and confused. I feel like I am pushing myself to maintain a normal life. My energy is gone so early in the day now. The confusion is now noticed by family members. I am scared and I do not know anyone with this disease. So, I tend to feel very alone and not understood about the changes I am going through. My family does and will not talk about this disease. I keep going to your site to read and understand and if there are any new answers.

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Comment from: PBC patient, 55-64 Female (Patient) Published: October 18

I was diagnosed with primary biliary cirrhosis (PBC) in 2010 at age 59. I am taking ursodiol 250mg. Symptoms: mild pain under rib on right side, ALP, ALT, AST are mild to medium elevations from normal . High cholesterol. Often tired. Often feel sleepy. I need to rest and sleep more than I used to. Itchy on arms, lower parts of legs. I'm now 62. Urso helps keeping my liver enzymes in normal ranges. Had 1 biopsy that confirmed the PBC. Had ultrasound tests, CTs and MRIs since the diagnosis, and the tests show a very slow progress of the disease since 2010, almost unchanged. I am still working full time.

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