Gout (cont.)

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What does the future hold for patients with gout and hyperuricemia?

Active research is ongoing in a variety of fields related to gout and hyperuricemia. The management of chronic gouty disease and its relationship to improving blood pressure and kidney function is becoming better defined.

Scientists have reported that high animal protein intake slightly increased the risk for gout. Others found that dietary calcium intake may protect patients from getting gout attacks. Vitamin C may also lower blood uric acid levels.

New medications to increase the elimination of uric acid in the urine (such as benzbromarone) are being evaluated in clinical trials. Researchers are also reporting on experimental drugs that can affect chemical messengers involved in gouty inflammation called interleukins.

The optimal regimens for the treatment of acute gout attacks and chronic gout conditions still require further long-term studies. Research scientists will continue to develop less toxic and more effective medications to battle this "scourge of the ages."

Medically reviewed by Kirkwood Johnston, MD; American Board of Internal Medicine with subspecialty in Rheumatology


Choi, J.W.J., et al. "Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: the Third Health and Nutrition Examination Survey." Arthritis and Rheumatism. 59 (2008): 109-116.

Edwards, N.L. "Clinical gout." Rheumatology 5th ed. Philadelphia, PA: Mosby Elsevier, 2011: 1859-1865.

Emmerson, B.T. "The management of gout." N Engl J Med 334.7 (1996): 445-451.

Klippel, John H., et al., eds. Primer on the Rheumatic Diseases. New York: Springer and Arthritis Foundation, 2008.

Ruddy, Shaun, et al., eds. Kelley's Textbook of Rheumatology, 6th ed. Philadelphia: Saunders, 2001.

Medically Reviewed by a Doctor on 10/9/2014

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